Advance in Herpesvirus US10 gene and its encoded protein / 中国人兽共患病学报

US10 gene of Herpesvirus is located in the short unique region of its genome and not essential for virus replication.US10 gene encodes a phosphorylated tegument-capsid associated protein or type Ⅰ transmembrane glycoprotein which selectively targets the cytoplasmic tail of HLA-G,a kind of nonclassical class Ⅰ MHC molecular,to reduce and block the host NK cell cytotoxicity in immune evasion.US10 can also interact with host proteins to play a pathogenic role and regulate the expression of other viral proteins such as glycoprotein E (gE).Through further research,the role of US10 in virulence and its ability to combine with RNA and regulate transcription can be judged in the future.